| 400m Individual Medley | 4:58.53 | CRONK Carli |  USA | 09 May 2022 | Caxias do Sul, Brazil |
| 400m Individual Medley | 5:04.07 | HE Yue Yue |  CHN | 28 Jul 2013 | Sofia, Bulgaria |
| 400m Individual Medley | 5:05.31 | TOVSTA Anna |  UKR | 07 Aug 2011 | Coimbra, Portugal |
| 400m Individual Medley | 5:08.21 | HE Yue Yue | CHN | 11 Sep 2009 | Taipei, Taiwan |
| 400m Individual Medley | 5:12.13 | BAILEY Cindy-Lu |  AUS | 11 Jul 1985 | Los Angeles, United States |
| 400m Individual Medley | 5:14.54 | BAILEY Cindy-Lu | AUS | 11 Jul 1985 | Los Angeles, United States |
| 400m Individual Medley | 5:19.22 | BARBER Laura | USA | 18 Jul 1980 | Cleveland, United States |
| 400m Individual Medley | 5:28.08 | BARBER Laura | USA | 18 Jul 1980 | Cleveland, United States |
| 400m Individual Medley | 5:31.19 | BARBER Laura | USA | 20 Jul 1977 | Bucharest, Romania |
| 400m Individual Medley | 5:36.62 | BARBER Laura | USA | 20 Jul 1977 | Bucharest, Romania |
| 400m Individual Medley | 5:44.5 | HAYES Cheryl |  CAN | 09 Apr 1977 | Saskatoon, Canada |
| 400m Individual Medley | 6:43.4 | EDWARDS G. |  URS | 30 Jul 1974 | Warszawa, Poland |
| 400m Individual Medley | 7.12.7 | GRüNBERGER Heidemarie |  GDR | 14 Jul 1968 | Rzeszow, Poland |
| 400m Individual Medley | 7:12.8 | GRüNBERGER Heidemarie | GDR | 14 Jul 1968 | Rzeszow, Poland |